Abreva Cold Sore Remedy

Abreva cold sore treatment



Abreva cold sore remedy is the new FDA approved OTC or other the counter cold sore treatment by GlaxoSmithKline, the manufacturer of Zovirax. Its new patented active ingredient is Docanosol. Docanosol can prevent replication of the herpes virus in healthy cells by making them momentarily "herpes proof".

Abreva also contains benzyl alcohol. Even though stated as a non active ingredient benzyl alcohol is a common drug preservative used for its anti-itching, anesthetic and antiseptic properties. So it may add some value to the product.

I have found interesting information on docanosol at one of GlaxoSmithKline's website: Dental Professional.com. Even though we're not dentist (at least I'm not) I think we deserve more thorough information than the superficial public product presentation that they make at Abreva.com.
So here is an interesting abstract from their FAQ at Dental Professional.com.

"What is docosanol?

Docosanol is the active ingredient in Abreva cold soer remedy. Docosanol has been clinically proven to shorten cold sore healing time. Docosanol and its metabolite (n-docosanoic acid) are present in many common foods and are virtually unavoidable in the diet. Common dietary sources of n-docosanoic acid include chocolate, peanuts, and certain oils. It also occurs in a variety of unprocessed fruits and vegetables.

What is the mode of action of docosanol?

Docosanol works by changing the cell membrane which surrounds healthy skin cells. The modified cell membrane acts as a barrier to the cold sore virus so that the virus cannot enter the cell to begin the process of infection.

Can you explain how Abreva's docosanol blocks cold sores?

Treating cells with docosanol alters the properties of the host cell membrane in a way that inhibits or blocks, the causative agent of cold sores – the herpes simplex virus – from entering the cell via its normal pathway. Although individual virus particles are not inhibited from attaching to or binding to the herpes virus specific receptors on the cell membrane, the viral envelope, and the cell membrane cannot fuse as is required for productive infection. Because there is no viral/cell fusion, the genomic material of the virus is less likely to enter the cell so viral replication cannot occur.*

Is docosanol an antiviral?

Docosanol is not classified as an antiviral. Typically nucleoside analogues, like penciclovir (Denavir®) and acyclovir (Zovirax®) are considered to be the only antivirals that are used in herpes labialis, and they are classified as antivirals because their activity occurs in virus-infected cells. Docosanol’s mode of action is distinct from this, in that its mode of action takes place only in healthy cells, where it works on the cell membrane to help inhibit the ability of the virus to fuse with the cell membrane so that the virus is less likely to enter the cell to begin the process of infection.

How does Abreva cold sore treatment compare to Denavir?

They are both approved to speed healing of cold sores. However, they work differently. Denavir is an antiviral whereas ABREVA is not. Denavir is available only by prescription whereas ABREVA is available OTC.

Does ABREVA cold sore remedy provide symptomatic relief?

Abreva cold sore ointment provides symptomatic relief as a result of the healing process. It is clinically proven to shorten the duration of symptoms, such as tingling, pain, burning, and itching. The cream is a soothing formula that contains no irritants.
Will ABREVA cold sore treatment work if a patient comes to me after a blister has already formed?
Best results with ABREVA are obtained when treatment stars early – at the tingle/bump/redness stage of the cold sore.
Can docosanol be used to prevent cold sores?
Docosanol has not been tested, nor is it indicated for preventing cold sores."(end of quote)

All right. But is Abreva cold sore remedy really efficient?

Abreva cold sore remedy eliminates the symptoms associated with oral herpes, cold sores and fever blisters in 2.2 days. So that is a pretty positive aspect of Abreva.
It reduces colds sores healing time to 4.1 days versus 4.8 days with a placebo. In other words this may mean that it reduces the healing time of cold sores by 0.7 day. So honestly I don't understand what the big fuss about.

My conclusion is you may consider Abreva cold sore remedy if your cold sores tend to take for ever to heal and are very painful and if you're the kind of person who needs a medical/FDA approved label to try anything. Abreva cold sore remedy appears to be safe. But I don't find the test results very exciting. You can check this information at Abrevapharmacist.com.

Here's the label information for Abreva:

Abreva Indications:

Treats cold sores/fever blisters on the face or lips.
Shortens healing time and duration of symptoms:
tingling, pain, burning, and/or itching.

Directions for Abreva cold sore treatment:

Adults and children 12 years or over:
Wash hands before and after applying cream.
Apply to affected area on face or lips at the first sign of cold sore/fever blister (tingle).
Early treatment ensures the best results.
Rub in gently but completely.
Use 5 times a day until healed.
Children under 12 years: ask a doctor.

Abreva cold sore treatment ingredients:

Active Ingredients: Docosanol 10% (Cold sore/fever blister treatment)

Inactive Ingredients: Benzyl Alcohol, Light Mineral Oil, Propylene Glycol, Purified Water, Sucrose Distearate, Sucrose Stearate

Warnings for Abreva cold sore treatment:

For external use only.
Do not use if you are allergic to any ingredient in this product.

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Your Abreva Reviews or Testimonials :

If I apply it when the first stinging/burning starts, it either completely stops the blister from forming, or makes them much smaller and faster healing. The key is repeated applications during the burning phase. Has made a tremendous difference for me.
Grade 4 (Good)
John
Apr. 1, 2008


THis did not help but irritate my skin.
Did not help get rid of my cold sore.

2 (Bad)
Anonymous Male, USA
Feb. 29, 2007

Did absolutely nothing beyond what CARMEX or any other medicated lip balm does. Definitley not worth the money.
1 (Dreadful)
Mark, USA
Nov. 26, 2007

I've been using abreva for about a year now. Within the course of 1 year, I've only had to use it 3 times. I apply it at the first signs of a cold sore on my lip. The first time I used it, it was effective in that it prevented the cold sore from appearing. The second time, it was less effective. I just used it for the third time yesterday and it had absolutely no effect on the cold sore, which was disappointing and frustrating. :(

1 (Dreadful)
Marcy, Ohio, USA

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More over the counter cold sore treatments:

Abreva Cold Sore Cream | Carmex for cold sores | Chapstick cold sore therapy
Pure Lip cold sore remedy | Releev for cold sores | Zilactin Cold Sore Relief Gel

By the way, if you hate, love, detest or adore a product for the OTC treatment for cold sores like Abreva cold sore remedy, please express yourself. Let me know by completing my herpes treatments testimonials form. That would be great to hear from you.

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