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Over the counter or OTC Treatment for Cold Sores Explained



OTC treatment for cold sores is non prescription medicine that can heal and/or alleviate fever blister symptoms. Oral herpes when activated causes itching, burning, redness then blisters and sores. Most of the OTC treatment for clod sores I've reviewed contains anesthetic or numbing agents to limit the pain and itching associated with cold sores. I think some of the OTC treatment for cold sores is inappropriate or inactive and could actually worsen symptoms. To further explain why I prefer a certain brand to another I think it's only fair that we take together a closer look at what ingredients are used in most over the counter cold sore products. I'm the kind of person who just doesn't take my pharmacist words for it and it appears I'm right. So to quote the titile of a book I like. "Don't go to the counter without me". I'm not saying all the cold sore over the counter products are bad. Actually, some OTC medicines for cold sores are safe and potentially effective. But usually the answer is not in the active ingredients. If you're feeling lazy and you don't to educate yourself about all those ingredients, you can directly to my cold sore OTC medecines and products review page.

In 1992 the FDA has released a very specific list of ingredients that could not be included as active ingredients in cold sore, herpes medicines. For more information Click here. However some of the same ingredients could still be included in the OTC treatment for cold sore formula if stated as non active ingredients. We know (or will know by further exploring this website) that some ingredients have been found active against herpes simplex 1 and 2, in preliminary scientific studies. Unfortunately these studies were considered as insufficient to meet FDA standards for OTC treatment for cold sores. FDA standards are useful because they protect citizens from dangerous and false claims. However they prevent cheap, easily available ingredients to be considered as active. In our society based on profit, who will spend a lot of money on an ingredient that cannot be patented? If one spends so much money proving that a product is safe and effective, it is quite natural that one wants a good return on their investment.

So if you want to go beyond the commercial logics imposed by our society and get what's best for you let's study what ingredients are unofficially but potentially active Later on , another document was released by the FDA mostly concerning OTC treatment for cold sores regulations mostly concerning lysine and probiotics. To see the document Click here.

So here are the main ingredients of OTC treatment for cold sores. This is by no means an exhaustive list but representative one of most commonly found ingredients in commonly used OTC treatment for cold sores.

Anesthetic, Analgesic or Numbing Agents for cold sores
Moisturizers, Emollient, Softening for cold sores
Antiseptic, Microbicidal agents for cold sores
Sun Screen for cold sores
Natural ingredients for cold sores

Anesthetic, Analgesic or Numbing Agents for cold sores:

A lot of OTC products include agents that can suppress the itching and the pain associated with cold sores and fever blisters. The most common ones are benzocaine, benzyl alcohol, camphor and phenol.

  • Benzocaine: Benzocaine is a topical anesthetic. It numbs wherever it is applied. It is commonly used in first aid creams and sunburn remedies. Benzocain is a compound made from the organic acid PABA (para amino benzoic acid) and the alcohol ethanol. It may cause allergic skin reactions such as rashes, flares or swelling and urticaria in more severe cases.
  • Lidocaine: Lidocaine is another topical anesthetic, similar to benzocaine. A relatively recent study has shown that lidocaine was not effective in relieving the pain associated with oral herpes infection. None of the OTC cold sore medecinesI present contain lidocaine. But I know several people who claim to alleviate the pain of their oral herpes symptoms by applying lidocaine gel on their fever blister regardless of scientific study results. Lidocaine gel is an OTC product that you can easily find online or at the drugstore.
  • Menthol: Menthol is usually included in OTC treatment for cold sore because it locally relieves pain and itching and causes a tingling sensation to the skin when applied. It is also used in throat lozenges, inhalers, and as a flavoring. Menthol is derived from the oil of the peppermint plant, Mentha piperita (peppermint), or prepared synthetically from coal tar (yak!). Let's hope we get the natural mint derived one. Menthol overdose can cause rather alarming but not dangerous symptoms (dizziness, convulsions, abdominal pain and blood in the urine or no urine...) so remember to keep your menthol gels and creams away from your children.
  • Camphor: Champhor is a local anesthetic and anti-itch that has a cooling effect like menthol. When ingested in large quantities it can be poisonous and can cause seizures, confusion, irritability, and neuromuscular hyperactivity. So once again, keep camphor containing products away from your children.
  • Benzyl Alcohol: Benzyl alcohol or phenylmethanol, phenylcarbinol is commonly used as a preservative in drugs. But it is used in cold sore medicine for its anti-itching, anesthtic and antiseptic properties. It has low toxicity but it can be lethal for very young babies if ingested in sufficient amount.
  • Phenol: Phenol is also known as carbolic acid. It can be made from the partial oxidation of benzene or coal. It has antiseptic and anesthetic properties but may cause skin irritation if used for a long period of time. Exposure of the skin to concentrated phenol solutions causes chemical burns which may be severe and phenol overdose can cause harmful side effects. That's why the FDA only allows very small concentration of phenol in OTC products. So OTC treatment for cold sores available on the market containing phenol should be very safe but should also be kept away from the reach of children.
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Moisturizers, Emollient, Softening agents for cold sores:

Lip balms can relieve dryness and soften the scabs that form on cold sores so they are less likely to crack and bleed. Apart from vegetable oil like cocoa butter, olive oil and almond oil, the three synthetic main ingredient are petrolatum white (vaseline), allantoin and lanolin.

  • Lanolin: Lanolin is a greasy wool by-product. It's also known as wool fat or wool grease. When purified, it is used as a base for ointments and creams, as a lubricant, and in finishing and preserving leather. It can cause allergies and irritate the skin. Keep away from children. It can cause vomiting and diarrhea when ingested.
  • Allatoin: Allantoin is a botanical extract of the comfrey plant and is used for its healing, soothing, and anti-irritating properties. It softens the skin, helps to heal wounds and skin irritations and stimulate growth of healthy tissue. It is used in OTC treatment for cold sores because it can help heal minor wounds and promote healthy skin.
  • Petrolatum (Vaseline): Petroleum jelly is derived from petroleum. It is widely used in medicinal ointments and often included in OTC treatment for cold sores. One major concern today is that the FDA doesn't evaluate the purity of petrolatum in personal care products even lipsticks or facial creams. In other words, manufacturers could use the same unregulated petrolatum in personal care products as the one used in shoe polish without being bothered. Further more, recent studies indicate that petrolatum is a potential human carcinogen and that it may promote breast cancer. I think it would be wise to keep away from lipsticks and balms that contain a lot of petrolatum if you live in the United States.
  • Salicylic Acid: Salicylic acid is the key additive in many skin-care products for the treatment of acne, keratosis pilaris and warts. Salicylic acid is a peeling agent which causes skin cells to slough off more readily. It can soften the skin and cold sore scabs by speeding skin cells renewal. Discontinue using if you have an open sore. Salicylic acid and its derivatives are toxic when consumed in large amounts which is highly unlikely when using OTC treatment for cold sores. You may however be allergic to it.
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Antiseptic, Microbicidal agents for cold sores:

We already have mentioned some antiseptic agents above, benzyl alcohol and phenol. But there are more antibacterial agents. Most of them won't have a direct effect on fever blisters or cold sores. But two antiseptic agents have been found to inactivate the herpes virus. So keep those two in mind as they somtimes appear in the inactive ingredient list of OTC treatment for cold sores.

Benzalkonium chloride: usually used as a spermicidal, an antimicrobial and an antiseptic agent. It was also found to kill herpes on contact in a scientific study.

Sodium Lauryl Sulfate: Sodium lauryl sulfate was found to be a microbicide effective against enveloped and non enveloped viruses and to increases the efficacy of a topical formulation in an animal study. For your information herpes is an envleoped virus. For more information Click here.

I must add one remark though. Dosage is an important factor and the higher on the list, the more concentrated an ingredient is. So if one of these two is last on the list, they may be in insufficient amount.

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Sun Screen for cold sores:

Sun exposure may trigger oral herpes and promote fever blisters. That's why many OTC treatments for cold sore include them in their formula in order to prevent cold sores. There are two kinds of sunscreen, one based on zinc oxide and the other synthetic ones, PABA, oxylbenzone and so forth...

Zinc oxide: Zinc oxide is a chemical compound, ZnO, which is nearly insoluble in water. Because it absorbs ultraviolet light, zinc oxide can be used in ointments, creams, and lotions to protect against sunburn. Zinc oxide is considered fairly nontoxic but if swallowed in large quantities it can cause reversible symptoms such as yellow skin abdominal, nausea... very unlikely to happen when using OTC remedies for cold sores.

Chemical sunscreens: Chemical sunscreens are the most commonly used. Most commercial sunscreen contains several UV radiation-absorbing chemicals. Some of the most widely used chemical groups that block UVB radiation are PABA (p-aminobenzoic acid), PABA esters (padimate O), cinnamates (cinoxate, ethylhexyl-p-methoxycinnamate), salicylates (octylsalicylate, homosalate), and anthranilates (methyl anthranilate). While these all block UVB radiation, the chemical group known as benzophenone (oxybenzone and dioxybenzone) provides protection against both UVA and UVB radiation. PABA has been banned from all sunscreen products in Europe since 2004. They're thought to potentially increase the risk of cancer. I don't know if you're aware that there's a growing concern about PABA usage safety. Actually an Oxford University scientist John Knowland has shown that PABA seemed to damage DNA, thus increasing the risk of skin cancer. He recommends using non-PABA products. Chemical sunscreen can cause allergic skin reactions in some cases such as a rash, irritation, itching, stinging, acne, redness, swelling and drying. Do not use oxybenzone and dioxybenzone products if you're allergic to, benzocaine, procaine, novocaine and the likes.

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Natural ingredients for cold sores:

Most of natural ingredients are considered non active. OTC treatment for cold sores often include them. But some studies indicate that they're may not be all inactive. Melissa officinalis, aloe vera, vitamin, some essential oils, green tea and over tannin and several plant extracts have shown efficacy in the lab. Most where in vitro studies and these kinds of studies are considered insufficient. But lysine, melissa, aloe vera and vitamin C as well as other natural ingredients received partial human studies unfortunately still considered insufficient by the FDA to validate as OTC treatment for cold sores. You can find more information on natural ingredients on several pages of this website: Home remedies for cold sores, herbal treatments for herpes, genital herpes herbal treatments

In conclusion, I would say OTC treatment for cold sores comes in many forms and some appear safe and effective and sometimes could do more than just alleviate symptoms. But according to FDA regulations it must be kept secret. But we know better now. Don't we?

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For a review of those products designed for the OTC treatment for cold sores click directly on the links below:

Releev for cold sores
Pure Lip cold sore remedy
Zilactin cold sore relief gel
Carmex for cold sores
Chapstick cold sore therapy
Abreva
and more to come...
By the way, if you hate, love, detest or adore a product for the OTC treatment for cold sores, please express yourself. Let me know by completing my herpes treatments testimonials form. That woul be great to hear from you.

More exciting cold sore remedies:
If you want to know more about cold sore medecines, herbal and natural treatment and learn more about OTC treatment for cold sores, this is the place to go to.

Relieve cold sore pain
If your cold sores get painful at times and your fever blisters won't leave you in peace, the information on this page could become very handy.

Homeopathic cold sore remedies:
Did you know that homeopathy could prevent and treat herpes and cold sores? Find out how and what cold sore homeopathic remedy may work best for you.